With a rich heritage and a research and development focus on specific aspects of neurodegenerative diseases, analgesia and psychiatry, AstraZeneca continues to push the boundaries of science in neuroscience in collaboration with other innovative partners across industry and academia. A significant unmet medical need remains in the areas of cognitive disorders, chronic pain and other central nervous system disorders.
More than 450 million people worldwide are affected by mental, neurological or behavioural problems, and the number is steadily rising.
AD is a fatal illness that causes progressive decline in memory and other aspects of cognition.
OIC is a condition caused by prescription opioid pain medicines. Millions of patients are treated with opioids each year.
We are committed to developing novel therapies that advance the science of neurodegenerative diseases and have the potential to provide a positive impact on patients around the world.
MEDI1814 is a monoclonal antibody currently in Phase I development as a potential disease-modifying treatment for Alzheimer’s disease (AD). MEDI1814 is the first antibody to selectively target amyloid-beta 42, a form of amyloid which is particularly associated with AD. The build-up of plaque in the brain containing the peptide amyloid-beta is one of the key characteristics of AD. Early trials have shown that MEDI1814 can reduce levels of this more toxic form of amyloid-beta in Alzheimer’s disease patients.
AstraZeneca and Lily are co-developing MEDI1814 as part of the BACE alliance.
Image: Artistic rendering of BACE enzyme.
Partnering with influential organisations to extend the reach of our science to more patients and healthcare providers
Our approach in Neuroscience looks to maximise revenue through externalisation and on-market products; advance the novel product pipeline with partnerships where appropriate; and preserve a company stake in the most promising assets.
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Veeva ID: Z4-17491
Date of next review: 07/06/2021